Planning a coupling and have no access to the big reaction databases? ReproRank gives you real procedures from pharmaceutical patents, ranked by how many independent organisations used them on substrates like yours. Suzuki–Miyaura couplings today, more coupling types to follow.
Send me a coupling you’re planningReaxys and SciFinder are the standard tools for finding how a reaction has been run before. They are licensed per organisation, and for a CRO of fifteen chemists, a five-person biotech or a group whose university does not subscribe, that licence is often out of reach.
The usual fallbacks are slow or unreliable: reading patents one by one on Google Patents, searching journal articles, asking a general chatbot that may invent a procedure, or going with the conditions you always use. None of them tells you which procedure has actually worked for other people on molecules like yours.
| Reaxys / SciFinder | ReproRank | |
|---|---|---|
| Coverage | Millions of reactions of every type, from journals and patents | Suzuki–Miyaura couplings from pharmaceutical patents (about 19,500); more coupling types planned |
| What you get | A list of matching reactions to read and compare yourself | A short ranked list of complete procedures, with how many organisations used each |
| Access | Institutional licence | Free 30-day pilot; pricing for small teams after the pilot |
| Best for | Broad literature searches across all chemistry | Choosing which coupling procedure to run first |
ReproRank does not replace a full reaction database. If you have Reaxys or SciFinder, it can sit alongside them and save the time spent reading through hits. If you don’t, it gives you the part of that work that matters most when you plan a coupling.
The pilot is free for 30 days, with as many searches as you like. Pricing for small teams will be set after the pilot.
Suzuki–Miyaura couplings today. Other common medicinal chemistry couplings are next.
No. Published or patented chemistry is enough to try it. Structures and names you enter are never stored, not even as a hash, and the service is hosted in the EU.
From pharmaceutical patents filed between 2003 and 2025, checked by a medicinal chemist.
ReproRank is built by Matthieu Desroses, a medicinal chemist with more than 25 years of experience in drug discovery, based in Stockholm, Sweden. More about the founder.
Email the two coupling partners (names or SMILES) and I’ll send back the ranked precedent procedures within two working days. Or ask for a pilot link and run the searches yourself.
Email pilot@reprorank.comStructures and names you enter on the site are never stored, not even as a hash. Hosted in the EU.